I usually take both Metaformin and glipizide to control my type 2 diabetes. I ran out out of the glipizide precription over the weekend and the Metaformin yesterday. I have been urinating much more frequently this week and my legs and feet have cramped up severely at night when I feel like I am dehydrated. I am drinking so much water during the day but urinating right away. I am picking up the prescriptions today , however both my calves are very sore from the cramping. Could I do any damage to my legs by missing the prescriptions and enduring the severe cramps? I feel like I lost some weight while not using the medicine and urinating a lot.