I was taking Zoloft and Seroquel for clinical depression and I got better,but still not 100 percent and had anxiety in the morning.I would take a 0.5mg of Klonopin and that would relieve the anxiety but I wanted to get off of it. My Dr. just called and told me that reason I am not fully recovered is my labs came back showing I have Hypoparathyroidism and that is causing the Zoloft not to fully work. I am going to see an endocrinologist next week .My question is-Once my thyroid levels are normalized ,shouldn't my depression lift with continued use of Zoloft. I have been a nurse for 30 years ,but am not knowledgable in this area. Hopefully you can give me a bit of hope/encouragement that I will feel better when the hypoparathyroidism is under control.Thanks so sos much