Iam taking Coumadin for 6years now due to a P.E. And have been diagnosed with Factor V Leiden. I never really recovered from the PE and I always feel fragile or weak sometimes. I will feel fine when I go to bed then 6hrs later wake up and feel like I got hit by a car. I have my inr checked and it is usually around 1.9. I just don't have the long lasting strength and stability I once had. Can the Coumadin be causing these conditions or is it a result of the Pulmonary embolism.