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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Igg Low, High Monos, Low Kappa And Lambada Light Chains, Intermittent Stomach Pain, Nighttime Cough. Advise?

Hi, my son will be 6 years old in August. He was frequently ill as a baby and toddler and we were sent to an immunologist. His IgG, IgA and IgM numbers were low and we are continuing to monitor him. His IgA and IgM are both finally within normal range but his IgG remains low at 386. His lab results also show high monos (8.8) and low Kappa and Lambda light chains (87 and 50 respectively). Does this sound like it could still be Trainsietn Hypogammaglobulinemia of Infancy at this point or should we be following up with further testing? I'm not sure if it is related, but he also has been complaining of intermittent stomach pain (lower, in the middle) to the point he needs to lay down until it goes away and he often has a bad nighttime cough. Thanks!
Thu, 23 May 2013
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Pediatrician,  's  Response
Transient hypogammaglobulinemia usually goes away before the second birthday, so it does not seem to be the same illness. At the same time, as his IgG is definitely low for his age, you should be worrying about some form of immune deficiency and schedule an appointment with an immunology consultant specializing in pediatrics as well.

I don't think an online query is possible to be answered given the complicated and unusual history and findings. The abdominal pain may be related to his primary disease, but it may also be unrelated and may need further testing.

Dr. Taher
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Igg Low, High Monos, Low Kappa And Lambada Light Chains, Intermittent Stomach Pain, Nighttime Cough. Advise?

Transient hypogammaglobulinemia usually goes away before the second birthday, so it does not seem to be the same illness. At the same time, as his IgG is definitely low for his age, you should be worrying about some form of immune deficiency and schedule an appointment with an immunology consultant specializing in pediatrics as well. I don t think an online query is possible to be answered given the complicated and unusual history and findings. The abdominal pain may be related to his primary disease, but it may also be unrelated and may need further testing. Dr. Taher