Hello, I understand your concern for acne and usage of isotretinoin for the same. Isotretinoin is the most important drug in treating acne. It is now the drug of choice for most the cystic or large acne as it helps in treating all the causes of acne formation. In males it is not very important to take any history or do any precautions except the blood investigations. As you are a female so it is quite important so it is quite very important to know you marital history or if married then history of conceiving in next few months. If you are married and want to conceive then you should not take this medication. But if you are unmarried then there is no problem in taking the medication as it is the most important medication to treat to earliest. An initial blood profile is mandatory before starting this tablet so just go for the blood investigations and liver function tests. All the best.