Hello, ESR and CRP (C-reactive protein) in Polymyalgia are often abnormally high. ESR which is commonly called a sed rate is a test that measures how much inflammation is in the body. Normal result for women over 50 years old is less than 30. Polymyalgia rheumatica is usually treated with a low dose of an oral corticosteroid (prednisone). At the beginning of the treatment the dose of the corticosteroid is usually 10 to 20 milligrams a day. Your doctor can slowly decrease the dose to find the lowest dose that keeps your symptoms and the results of sed rate (ESR) and CRP under control. If patient symptoms do not respond initially to this dose, the prednisone dose should be increased to 30 milligrams a day. Please note that corticosteroids can cause side effects like: - osteoporosis which is the loss of bone density and increases the risk of bone fractures, - high blood pressure and cholesterol level, - weight gain which is very common, - thinning of the skin, - cataracts You should be checking for these problems by your doctor during follow-up visits. To help prevent osteoporosis Your doctor should prescribe You calcium and vitamin D supplements. Hope I have answered your question. If you have any further questions I will be happy to help.