HI, thanks for using healthcare magic These medications , when used together, require very careful monitoring for interactions. Adderall is a combination of two medications amphetamine and dextroamphetamine. They (adderall and prozac) both increase the levels of serotonin and this can cause serotonin syndrome. Serotonin syndrome can cause tremors, headache, confusion, agitation, seizures, nausea, vomiting, increased heart rate, increased blood pressure. In addition the prozac also increases the levels of dextroamphetamine, one of the ingredients in adderall which means that it would have more side effects since its levels are higher I hope this helps