Hi, Celebrex is a painkiller which belongs to a group called Non steroidal anti inflammatory drugs. Prednisone is a steroid which is also a powerful anti inflammatory drug. Since you have osteoarthritis and Crohn s disease, steroids can be prescribed. As your pharmacist has advised, when using steroids, start with a low dose and gradually increase if required. Similarly on stopping the drug, gradual reduction of the drug is essential. There are certain conditions in which the drug must be cautiously used which may include diabetes, hypertension, peptic ulcer, acute infections. Kindly consult with your physician regarding the same. Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Saranya Ramadoss, General & Family Physician