Is electroconvulsive therapy a problem for an elderly man - 76, apoe 3/4 - who has mild short-term memory loss? Lifelong major depression, self-medicated with work, can no long work. Took Elavil in 70s, now takes Effexor + 10mg Abilify. Feels he s at the end of his useful life, feels hopeless. Major, major depression.