hi dear
vertin contains betahistine salt which is meant to treat chronic labrinthine disorder
i am briefing you the mechanism of action of beta histine
Betahistine has two modes of action. Primarily, it has a direct stimulating (agonistic) effect on H1 receptors located on blood vessels in the inner ear. This gives rise to local
vasodilation and increased permeability, which helps to reverse the underlying problem of
endolymphatic hydrops.
More importantly, betahistine has a powerful antagonistic effects at H3 receptors, thereby increasing the levels of
neurotransmitters histamine,
acetylcholine,
norepinephrine, serotonin, and GABA released from the nerve endings. The increased amounts of histamine released from histaminergic nerve endings can stimulate receptors. This stimulation explains the potent vasodilatory effects of betahistine in the inner ear, that are well documented.
Betahistine seems to dilate the blood vessels within the inner ear which can relieve pressure from excess fluid and act on the
smooth muscle.
It is postulated that betahistine's increase in the level of serotonin in the brainstem inhibits the activity of vestibular nuclei.
so for acute phase of dizziness vertin was ok but now as primary problem of your mother was
hypertension ,not labyrinthine disorder betahistine should be stoppped and she should be maintained on a dose of telmisartan on which her b.p is normal
thanks