Hello Dear. To tell you in brief its not good to take parocet in increasing doses as it affects the kidneys. To give you detailed answer: Percocet contains a combination of acetaminophen and oxycodone. Oxycodone is an opioid pain medication. An opioid is sometimes called a narcotic. Acetaminophen is a less potent pain reliever that increases the effects of oxycodone. Percocet is used to relieve moderate to severe pain. Important information: You should not use Percocet if you have recently used alcohol, sedatives, tranquilizers, or other narcotic medications. This medicine can slow or stop your breathing, and may be habit-forming. Use only your prescribed dose, and swallow the pill whole to avoid a potentially fatal dose. Never share Percocet with another person. MISUSE OF NARCOTIC MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription. Do not take more Percocet than is recommended. An overdose of acetaminophen can damage your liver or cause death. Call your doctor at once if you have nausea, pain in your upper stomach, itching, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of your skin or eyes). Before taking this medicine You should not use Percocet if you are allergic to acetaminophen (Tylenol) or oxycodone, or if: you have severe asthma or breathing problems; you have a bowel obstruction called paralytic ileus; or you have recently used alcohol, sedatives, tranquilizers, or other narcotic medications. Some medicines can interact with oxycodone and cause a serious condition called serotonin syndrome. Be sure your doctor knows if you also take medicine for depression, mental illness, Parkinson s disease, migraine headaches, serious infections, or prevention of nausea and vomiting. Ask your doctor before making any changes in how or when you take your medications. To make sure Percocet is safe for you, tell your doctor if you have: 1. any type of breathing problem or lung disease; 2. liver disease, cirrhosis, or if you drink more than 3 alcoholic beverages per day; 3. a history of drug abuse, alcohol addiction, or mental illness; 4. diarrhea, inflammatory bowel disease, or a blockage in your stomach or intestines; 5. kidney disease, urination problems; 6. problems with your gallbladder, pancreas, or thyroid; 7. a history of head injury, brain tumor, or seizures; or 8. if you use a sedative like Valium (diazepam, alprazolam, lorazepam, Ativan, Klonopin, Restoril, Tranxene, Versed, Xanax, and others). Percocet is more likely to cause breathing problems in older adults and people who are severely ill, malnourished, or otherwise debilitated. Percocet side effects: Get emergency medical help if you have signs of an allergic reaction to Percocet: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This could occur even if you have taken acetaminophen in the past and had no reaction. Stop taking Percocet and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling. Like other narcotic medicines, oxycodone can slow your breathing. Death may occur if breathing becomes too weak. Call your doctor at once if you have: 1. shallow breathing, slow heartbeat; 2. a light-headed feeling, like you might pass out; 3. confusion, unusual thoughts or behavior; 4. seizure (convulsions); 5. problems with urination; 6. infertility, missed menstrual periods; 7. impotence, sexual problems, loss of interest in sex; 8. liver problems - nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or low cortisol levels - nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness. Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea. Hope i have answered your question. Feel free to contact me if you have any more questions. I ll be glad to help you. All the best With warm regards Dr Sanjay Kini