Hello, Since you are pre-menopausal & having libido issues so you are irritable, mood swings & flushes are common in this phase of life. You are suggested to visit a gynecologist & get physically examined. You may need some medications (Fibanserin-Addyi) to boost your libido or you may require hormone replacement therapy (estrogen in the form of pills, gels, sprays or patches) effectively increase libido. Get treated. When Promestriene vaginal eggs are not suiting you & making you irritable, you may not use them. Visit a counselor with your partner, couple counselling by a therapist is helpful & effectively increases feelings of intimacy & desire. Sometimes, there is absolutely no problem but ladies get too conscious about their being pre-menopausal & invite Psychosomatic related libido issues. Stay carefree & stress-free. Use vaginal lubricants & take vitamin E. Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Nupur K, General & Family Physician