Thanks for your question on Healthcare Magic. I can understand your concern. Yes, patient should definitely start anti tubercular drugs if her placental tissue is positive for TB infection. Not only mother, child should also investigated for tuberculosis and if any doubt, child should also start anti tubercular drugs. Standard four drug anti TB treatment (rifampicin, isoniazid, pyrazinamide and ethambutol) are advised. Weight gain and fluid retention are not side effects of these drugs. No no need to worry for these side effects. Gastritis, nausea, vomiting, weakness, decreased appetite etc are common side effects which can be treated by antacid and anti Emetic drugs. So patient and her baby, both should start anti tubercular treatment without fear of side effects. Hope I have solved your query. I will be happy to help you further. Wishing good health to the mother and baby. Thanks.