Hi, Pioglitazone (Pioglit) is a medication used to treat type 2 diabetes by increasing the body s sensitivity to insulin, which helps to control blood sugar levels. However, weight gain is a known side effect of pioglitazone, and it can cause fluid retention in the body, leading to an increase in body weight. It is not uncommon for people to gain weight while taking pioglitazone. However, if you have noticed a significant increase in your weight in a short period after starting the medication, it s important to speak to your doctor about it. Your doctor may recommend adjustments to your medication or lifestyle changes to help manage your weight. This may include a change in your diet or exercise routine. If you do decide to discontinue the use of pioglitazone, it is possible that you may lose weight. However, it s important to note that stopping the medication without your doctor s advice can be dangerous, as it may lead to a sudden increase in your blood sugar levels. It s essential to follow your doctor s advice and maintain a healthy lifestyle to manage your diabetes and hypertension effectively. You should also continue to monitor your weight and discuss any changes with your doctor. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Diwashish Biswas, Internal Medicine Specialist