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Is It Safe To Take Amaryl Insted Of Cetapin While Suffering From Chronic Liver Disease?
I have been taking Cetapin xr 500 in the morning as well as in the night after meals. I have chronic parenchymal liver disease(I don t drink any alcohol),I was advised to stop Cetapin and to take .5mg Amaryl both in the morning as well as in the evening in lieu of Cetapin.Now I have started taking Udiliv 300mg one each in the morning and evening as advised by the Gastro Enterologist. My question is whether Amaryl is more safe than Cetapin in the wake of my present condition of the liver.Please advise .
Fri, 10 Apr 2020
Hi,
It is not safe to take amyl while suffering from chronic liver disease. Ceptin does not appear to cause or exacerbate liver injury and actually it is beneficial in patients with chronic liver disease. Ceptin is only contraindicated if you have advanced cirrhosis particularly with encephalopathy which may cause hypoxia thereby increasing the risk of a serious condition called lactic acidosis.
Amaryl is metabolized in the liver and excreted in the urine and feces. Patients with chronic liver disease treated with amaryl may be exposed to higher serum drug concentrations, which can increase the potential for severe hypoglycemia. In the presence of liver disease amaryl should be used cautiously by reducing its dosage and longer intervals between dosage adjustments may be required.
Moreover, hypoglycemia, if it occurs during treatment, may be prolonged in liver disease because of slowed metabolism and/or excretion of the drugs. So, in view of the above it is not advisable to take amaryl while suffering from chronic liver disease.
Hope I have answered your question. Let me know if I can assist you further.
Regards,
Dr. Mohammed Taher Ali, General & Family Physician
It is not safe to take amyl while suffering from chronic liver disease. Ceptin does not appear to cause or exacerbate liver injury and actually it is beneficial in patients with chronic liver disease. Ceptin is only contraindicated if you have advanced cirrhosis particularly with encephalopathy which may cause hypoxia thereby increasing the risk of a serious condition called lactic acidosis.
Amaryl is metabolized in the liver and excreted in the urine and feces. Patients with chronic liver disease treated with amaryl may be exposed to higher serum drug concentrations, which can increase the potential for severe hypoglycemia. In the presence of liver disease amaryl should be used cautiously by reducing its dosage and longer intervals between dosage adjustments may be required.
Moreover, hypoglycemia, if it occurs during treatment, may be prolonged in liver disease because of slowed metabolism and/or excretion of the drugs. So, in view of the above it is not advisable to take amaryl while suffering from chronic liver disease.
Hope I have answered your question. Let me know if I can assist you further.
Regards,
Dr. Mohammed Taher Ali, General & Family Physician
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