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Dr. Andrew Rynne
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Dr. Andrew Rynne

Family Physician

Exp 50 years

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Is It To Be Concerned About Thalassemia Or Another Inherited Blood Disorder If MCV Level Is Low?

My 10 year old son was recently tested for von willebrand's disease - I have type 1. The results came back in the normal range (COAG Factor VIII Activity 50%) But his MCV is low (74.7) and his MCH is barely in the normal range (25.4) Should I be concerned about thalassemia or another inherited blood disorder? Thank you
Thu, 14 Aug 2014
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Pathologist and Microbiologist,  's  Response
Hi,
Thanks for asking.
Based on your clinical history and query, my opinion is as follows:
1. Before going to thalassemia, get his ferritin levels tested. Iron deficiency is the commonest cause of low MCV
2. There are other causes like sideroblastic anemia, copper deficiency, anemia of chronic disease and lead poisoning.
3. Better to get a hemoglobin electrophoresis of your son, to rule out thalassemia. Even if it is thalassemia, it will be mild one, which wont affect his life. If it was serious type, it could be the presenting symptom before five years.
Hope it helps.
Any further queries, happy to help again.
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Is It To Be Concerned About Thalassemia Or Another Inherited Blood Disorder If MCV Level Is Low?

Hi, Thanks for asking. Based on your clinical history and query, my opinion is as follows: 1. Before going to thalassemia, get his ferritin levels tested. Iron deficiency is the commonest cause of low MCV 2. There are other causes like sideroblastic anemia, copper deficiency, anemia of chronic disease and lead poisoning. 3. Better to get a hemoglobin electrophoresis of your son, to rule out thalassemia. Even if it is thalassemia, it will be mild one, which wont affect his life. If it was serious type, it could be the presenting symptom before five years. Hope it helps. Any further queries, happy to help again.