Hello. Thank you for your questıon and welcome to HCM. I understand your concern. The combination of Losartan with Hydrochlorthiazide is a good, effective and safe strategy used for treating high blood pressure. There is no medication known which carries a 0% risk when it is used. Judging from the beneficiary point of vıew, then it is absolutely safe to use this combination. Not that this is not a good strategy to treat hypertension, since it is proven effective, but, if I were your doctor, I would recommend any drug from a class that has also heart rate-lowering properties, which help reducing the heart s workload. These classes are beta-blockers and calcium channel blockers. Another thing to be said, once the dıagnosis of hypertension is properly determined, strategy of controlling it continues for a lifetime. In the end, you should have a diet low on salt, rich in fibres and have 60 minutes of physical activity a day (walking, biking, going to the gym etc.) I hope I was of help. Take care. Good day, Dr. Meriton