Hi, Phytoestrogen is safe during menopause but it is fully effective during menopause hasn t confirmed yet according to the researchers. Unlike hormone replacement therapy, it doesn t increase the risk of clotting incidents in menopausal women. Women who have contraindications to hormone replacement therapy, they can use Phytoestrogen according to their physicians advice as it is safe and partially effective to hormone replacement therapy according to the researchers. So, it is an alternative to hormone replacement therapy and may be beneficial for women to rebalance their hormones during their menopause according to some researchers. Again some researchers are against its using during menopause as the evidence for the useful effects of Phytoestrogen is minimal. A doctor is a best judge to choose phytoestrogen or hormone replacement therapy for the women during their menopause. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Zubayer Alam, General And Family Physician,