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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Is Reticuloendotheliosis A Hereditary Disease?

I am a 43 year old male. When I was 1 to 2 years old, I had some form of reticuloendotheliosis. My parents recall it being described as a rare blood disease that was difficult to diagnose. It caused my spine to curve and my father recalls that it had eaten away at two of my vertebrate. My parents were told that it was something that would either prove fatal or it would "burn itself out". It did not prove to be fatal and I have no lasting effects from it. I now have a daughter who is 3 years old. She has begun to have some strange symptoms -- extremely elevated fever (105) with no other symptoms, and often complains of back pain. I am trying to learn more about the form of reticuloendotheliosis that I might have had and whether it is hereditary and consistent with my daughter's symptoms.
Mon, 9 Feb 2015
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Pathologist and Microbiologist 's  Response
Hi
Thanks for asking
Based on your query my opinion is
1. You have not given full details regarding the disease you were diagnosed as a child.
2. Based on the details of back ache and diagnosis of reticulocyte endotheliosis it appears you would have had a solitary manifestation of Langerhans cell disease.
3. This is not hereditary and is caused mostly due to a viral infection as neonate/ solvent exposure / childhood vaccination.
4. Unifocal disease especially bone lesions carry a good prognosis besides spontaneous regression or disease progression to multiorgan involvement.
5.Thats probably what you were informed about your disease that there would be possible spontaneous regression/ burnt out.
6. In your daughter's case, fever might just be of viral cause with backache/ generalized body aches.
7. If in doubt you can get counts checked apart from doing a x ray for any lytic lesion to rule out reticulocyte endotheliosis.
Hope this helps
Regards
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Is Reticuloendotheliosis A Hereditary Disease?

Hi Thanks for asking Based on your query my opinion is 1. You have not given full details regarding the disease you were diagnosed as a child. 2. Based on the details of back ache and diagnosis of reticulocyte endotheliosis it appears you would have had a solitary manifestation of Langerhans cell disease. 3. This is not hereditary and is caused mostly due to a viral infection as neonate/ solvent exposure / childhood vaccination. 4. Unifocal disease especially bone lesions carry a good prognosis besides spontaneous regression or disease progression to multiorgan involvement. 5.Thats probably what you were informed about your disease that there would be possible spontaneous regression/ burnt out. 6. In your daughter s case, fever might just be of viral cause with backache/ generalized body aches. 7. If in doubt you can get counts checked apart from doing a x ray for any lytic lesion to rule out reticulocyte endotheliosis. Hope this helps Regards