Hello and thank you for asking! Insulin is a hormone made by your pancreas. It allows your cells to use glucose (sugar) for energy. People with insulin resistance have cells that don’t use insulin effectively It’s not entirely clear why some people develop insulin resistance and others don’t. Being overweight or obese are the leading risk factors. A sedentary lifestyle can also cause insulin resistance, especially if you’re also overweight. Hypothyroidism can cause isnuline resistance only if left untreated, indirectly by causing overweight. For a personalised comprehensive evaluation, treatment recommendations, or individual therapy, ask me at HealthCareMagic at this private link: HCM Dr. Guni Best wishes, Dr.Mirjeta