Hi,
There are various conflicting reports of association of PPI to bone strength and
bone density. This effect, if any, may be due to negative effect of PPI on the calcium absorption from intestine. However, some studies suggest that these have no effect on bone density, but they have negative effect on bone strength, probably by their effect on osteoclastic activity thus affecting the remodeling of bones. Hence, most of the studies show no relationship between PPIs and
osteopenia or
osteoporosis.
However, there are some studies which show an increased relationship between PPI and bone
fractures particularly with hip fractures and fractures of spines. Also, there are very limited studies about effect on bone loss or bone strength, if any, about the comparative likelihood of these effects by different PPIS. Still, with whatever, evidence we have,
Pantoprazole appears to be safest PPI as regards to negative effect on bones, if any.
Take care. Hope I have answered your question. Let me know if I can assist you further.
Regards,
Dr. Satnarain Bansal, General & Family Physician