Hi! I have two son s and one daughter (14, 4 and 11 years). My oldest son has ADD, my daughter has juvenile rheumatoid arthritis and a hearing condition on the left ear, and my youngest son has autism and mild mental retardation. I came across Fragile X on the Internet and I get more and more convinced that this is the reason for at least my sons problems. My oldest son has prominent ears, low muscle tonus, he use to flap his hands when he was a baby, flat feet. my youngest son has rather prominent ears, flexible joints, low muscle tonus, flapping hands, flat feet. I know that Fragile X can be tested by a blood sample and I have off course tried to get hold of my kids doctors, so eventually I hope tests will be taken. My question is about my daugthers juvenile rheumatoid arthritis. Is there any known connection between this and Fragile X?