Hi
Thanks for using Health Care Magic Forum,
Casues of periventricular
white matter (PWM) lesions include normal senescent changes (then they are called UBO's, for "unidentified bright objects), small strokes, and disorders related to multiple sclerosis (MS). PWM are correlated with vitamen B6 (
pyridoxine) deficiency.
Getting older: Age is certainly the single most common cause of PWM. This is presumably a "wear and tear" phenomenon.
Small strokes: A period of
hypertension is a common cause. In the authors experience, just a few days of extreme hypertension may be enough. This might suggest that small bleeds are the cause in some. Clinical studies also show association with
diabetes, but not consistently with
atherosclerosis. PWM are often an accompaniment of migraine, and occur in roughly 20% of persons with migraine. As about 10% of the population has migraine, this means that about 2% of the population has white matter lesions due to migraine. PWM are also more common in persons with frequent syncope and orthostatic intolerance
I Hope I Provided Useful Information. Do ask Furthur Questions to help You get well soon.
Regards
Dr.J.Kingson John David