WELL WOULD SURELY TRY TO RESOLVE YOUR PROBLEM. IT LOOKS YOU ARE ALREADY UNDER TREATMENT OF SOME ENDOCHRINOLOGIST.THERE CAN BE VARIOUS REASONS FOR REDUCED RESPONSE OF BOTH THE DRUGS. 1.AUTOIMMUNITY-SOMETIME THYROXINE MOLECULS ARE DESTROYED BY BODY DISTURBED IMMUNE SYSTEM,SAME OCCUR IN CASE OF INSULIN. 2.DECREASED GASTRIC SECRETION ,USE OF ANTACIDS WITH DRUGS REDUCES ABSORPTION OF THYROXINE. 4)DELAYED EMPTYING OF STOMACH DUE TO ANY CAUSE WILL REDUCE THE ABSORPTION. 5)DEVELOPEMENT OF RESISITANCE OF BOTH THYROXINE AND INSULIN IS VERY COMMAN. 6)LEVOTHYROXINE JUST AN ENTOMER (MIRROR IMAGE),CHEMICALLY SAME,OF THYROXINE SHOULD HELP YOU WITHOUT ALTERING DRUG DOSES. 7)INSTEAD OF HUMAN INSULIN PORK INSULIN MAY OVERCOME AUTOIMMUNE REACTION. ANOTHER FACTOR CAUSING INSULIN MALFUNCTION IS HEAT.ALWAYS KEEP INSULIN REFRIGIRATED.(HEAT RENDER PROTIEN DENATURE). 8)YOU CAN ASK YOUR DOCTOR FOR POSSIBILITY OF PIOGLITAZONE+METFORMINE+GLIMPRIDECOMBINATION ADMINISTRATION FOR YOU. 9)CONSUME MORE PROTIEN AS PROTIEN DEFICIENCIES MAY LEAD TO BOTH INSULIN AND THYROXINE DEPLITION,AFTER ALL BOTH ARE PROTEIN. (POSSIBLY CHANGING TO LEVOTHYROXINE ,ORAL HYPOGLYCEMIC COMBINATION PIOGLITAZONE+GLIMPRIDE+METFORMIN ,WITH BALANCED DIET WITH MORE PROTEIN WILL HELP YOU,KINDLY USE THESE ALL MEASURES IN SUPERVISION OF ENDOCRINOLOGIST.) MOST OF PEOPLE GO UNDERNOURISHED BY DIETING FOR DIABETES CONTROL,AVOID THIS AND HAVE BALANCED DIET.