Dr. Shantharam, I am 53 yrs. old male Normotensive but suffering with NIDDM since 1987. BMI is 21. Incidentally the Serum Creatinine was detected to be 1.9 in the year 1995. (Case of Diabetic Nephropathy was excluded). Since then periodic renal function checking is being done. Now the Sr. Creatinine level is varying from 1.9 to 2.2. The Maintained BP is 130/80 mmHg. To delay the progression of the renal disease I have been asked to keep BP less than 125/75 mmHg. So I was taking Telmisertan 80 once for past 5 years. Now I have been advised to add Amlopdipine 2.5 once for past 2 weeks. The BP is not getting lowered further. For controlling the diabetes I am taking Gliclazide 80, 3 tablets per day. Kindly advise to protect my renal function from further deterioration. With best Regards, RK Saha Durgapur, West Bengal, India.