Hi, I have suffered with depression now on and off for around 10 years since an abusive relationship. My medication had been increased from 20mg citalopram to 40mg in June 2012, and this had worked fairly well until the beginning of the year, when I was tried on a combination of Citalopram and Mirtazepine 15mg, but this over sedated me. Recently, around 5 weeks ago I was prescribed Sertraline 50mg with the Citalpram 40mg. To begin with I felt great, apart from insomnia, I am continuing on the medication but the insomnia continues. I am unable to sleep until around 3am and then I find it hard to get out of bed. I'm also experiencing mood changes. Should I be taking this combination? I've been trying to research it and all the articles I read point to the same conclusion, that they are both serotonin uptake inhibitors and the combination is not recommended? Any advice would be great, Thanks, Mel