Hello, Thanks for choosing health care magic for posting your query. I have gone through your question in detail and I can understand what you are going through. its very much possible that your grand daughter may be having depression and that is leading to her being over weight. That should be certainly taken care of, and that can possible with the help of Psychiatry consultation. There are good medication like bupropion fluoxetine which can improve her depression with increasing her weight further and also try to start on her cognitive behavioural therapy which will focus her on weight loss. Hope I am able to answer your concerns. If you have any further query, I would be glad to help you. In future if you wish to contact me directly, you can use the below mentioned link: bit.ly/dr-srikanth-reddy Wish you good health, Kind regards Dr. Srikanth Reddy M.D. Neuro-Psychiatrist and Sexologist