Thanks for your question on Healthcare Magic. I can understand your concern. Ultram is having tramadol. It is centrally acting painkiller. It is good for pain management after total knee replacement. You were also having cellulitis. So you should also take pregabalin for nerve related pain relief. Also do physiotherapy, ultrasound application and warm water pad /ice pack application for better symptomatic relief. Painkiller creams containing diclofenac is also useful in such cases. So follow above mentioned things and you will improve in pain. Hope I have solved your query. I will be happy to help you further. Wish you good health. Thanks.