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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Project On Migraine. Drug Combination Of Naproxen And Propranolol Gives Anti Hypertensive Effect. Its Appropriate Dosage?

hey! i m a pharm. student and my final project on migraine. i choose drug combination of naproxen and propranolol. i mean naproxen act as NSAID and propranolol gives anti hypertensive effect or gives calmness. i am also confused which type of dosage form suitable (fast dispersible or oro dispersible or sustain release or any other dosage form).
half life of naproxen is 15 hr and half life of propranolol is 4 hr.
Tue, 17 Sep 2013
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General & Family Physician 's  Response
Hello.Naproxen is used for its anti-inflammatory effect and propranolol by vasoactive effect (according to the theory that explains the migraine vasoconstriction-vasodilation).
Naproxen is used to treat migraine attacks at a dose of 500 mg twice-thrice a day.Propranolol is used to prevent migraine attacks at a dose of 80-240 mg per day (divided into 3 doses).
Good luck with your final project.Regards.
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Project On Migraine. Drug Combination Of Naproxen And Propranolol Gives Anti Hypertensive Effect. Its Appropriate Dosage?

Hello.Naproxen is used for its anti-inflammatory effect and propranolol by vasoactive effect (according to the theory that explains the migraine vasoconstriction-vasodilation). Naproxen is used to treat migraine attacks at a dose of 500 mg twice-thrice a day.Propranolol is used to prevent migraine attacks at a dose of 80-240 mg per day (divided into 3 doses). Good luck with your final project.Regards.