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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Severe Brain Shocks, Mood Swings, Anxiety After Withdrawal From Paroxetine And Changing To Fluoxetine. Guide

Hi, I am currently withdrawing from Paroxetine. I have taken 4 months to reduce from 40mg to 20mg and have been advised to change to Fluoxetine whilst I begin a further slow withdrawal. I have now been using Fluoxetine for four days and have been having such severe brain shocks and huge emotional meltdowns, anxiety and overreactions. My question is : shall I persevere or return to Paroxetine. How long before the Fluoxetine kicks in ?
Tue, 11 Jun 2013
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Psychiatrist 's  Response
Hi there ~

I understand your concerns. It is not uncommon to have withdrawal reactions from switching from paroxetine to fluoxetine. One way of decreasing if not entirely eliminating these withdrawals is to reintroduce paroxetine and to go down on the dose in a very very gradual manner. Gradually titrating down the dose of paroxetine would be the answer to your problem. Fluoxetine can be used when the taper happens over a period of 2-3 weeks, when the action of fluoxetine usually sets in and its dose may be titrated up at that time. I hope this helps.

Take care and have a lovely day!
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Severe Brain Shocks, Mood Swings, Anxiety After Withdrawal From Paroxetine And Changing To Fluoxetine. Guide

Hi there ~ I understand your concerns. It is not uncommon to have withdrawal reactions from switching from paroxetine to fluoxetine. One way of decreasing if not entirely eliminating these withdrawals is to reintroduce paroxetine and to go down on the dose in a very very gradual manner. Gradually titrating down the dose of paroxetine would be the answer to your problem. Fluoxetine can be used when the taper happens over a period of 2-3 weeks, when the action of fluoxetine usually sets in and its dose may be titrated up at that time. I hope this helps. Take care and have a lovely day!