I am 76+ Vegetraian , retd in 2005from Sugar Industry but with little physical activities now , a known case of Diabetes II & BP both under control with HbA1c below 6.5. Recently I hd . seen a programme on Hypoglycemia , wherein it was mentioned that in case of eledrly persons with known cases of Diabetes II , there may not be any symptoms like running down ,exhaustion etc, before an attack of Hypoglycemia. Earlier I was taking Glyciphage Tab for Diabetes Control , which was replaced by Amryl , but during Jan 2011 , executive check up , the Consulting Dr replaced it by Amryl M 1 , twice a day ,. Though I am taking Amryl M since Jan 2011 with good control on Diabetes & other parameters incl Renal , LFT , Ultrasound etc.being normal and self of own expressed a desire to change Amryl M for any long term side effects but Drs hv advised to continue. Recently the Dr in Hypoglycemia programma has advised to replace Amryl M 1, by Tab Istameit 50+1000. May I hv yr learned views about the change pl , recommendations for the change pl. Thanks S.P.Jain