Hi, I have gone through your medical history carefully and understood your concerns. You are reporting to have mood changes: angry all the time and just unhappy; no sex drive or desire at the point to hate your husband. You say to be 56 years old. All these symptoms are related to menopause. Hormonal changes during this period are also causing your mood to fluctuate. And all this is normal. You should calm yourself down and reflect about your current problems. Talk to your husband about menopause and changes during this period. If he can t help you manage your psychological issues, then, can discuss further with a specialist: psychologist can help. Avoid caffeinated drinks in excessive amount and especially in the afternoon. Avoid alcoholic beverages: non more than a glass of wine per day. Crestor is not causing such side effects in mood changes. However, I advise to avoid its use along with alcohol. Remember, Crestor won t do magic for your cholesterol numbers. Diet and lifestyle changes can help maintain healthy range of cholesterol. Hope this helps.