hi, I have sjogrens syndrome (extra glandular) fibromyalgia, depression that has been continually treated but is not responsive to many types of antidepressants. Lately I have had terrible mood swings causing lots of irritablility and agitation. My dr. prescribed 50mg of apo - quetiapine for 3 nights then 150 mg on the fourth. On the fourth night, I could not sleep until I passed out many hours later after having severe pain and muscle problems and circulation problems in both legs (mostly my right) as well as headache, fatigue and dizziness. I am going back to the 50 mg tonight because of that. Today my legs have been hurting (joints, muscles)... I have positive ANA 1:320 speckled pattern, positive RF, high esr, and positive panel for sjogrens syndrome, but not the positive dna. I regulary have muscle fatigue, short of breath, and muscle pain after exherstion, I have low diffusive oxygen lung capacity of 69%. Total lung capacity of 80%, I have mild copd. I am 46, female, 5' 7 and 140 lbs. I have gained weight this year, my usual weight is between 132 and 135. I am supposed to see a pulmonary dr but it takes time to get in. I wish I knew how to fix this fatigue, depression and pain. I get walking excersising but lately not much because the humidity is killing me. My doctor is not hugely concerned about the low oxygen diffusion capacity because it says I only have mild copd, however breathing seems to be an issue especially in the heat . It is the shortage of breath on exherstion which is tough. I definitely have to stay out of the sun. Do you have any ideas about all this condition that could help me. Or any ideas that I should look at and point out to my dr. Oh yes, I also have gall stones and have had kidney stones ( they didn't find any, three times that I went to the hospital, and just treated the terrible pain) ..any ideas of what I could do to make this better?... I think I did have a reaction to the 150 mg..of apo-quetiapine so I am going to take less 50mg tonight...I am afraid to just cut it out. I will call dr. tomorrow...not sure