What would be a replacement for Duloxetine? I did a drug interation checker and had 4 pretty serious interactions. Its making me very depressed, grouchy and tired. I also feel short of breath. I am on clonazapam, clonadine, topiramate, wellbutrin sr ,tizanadine, and take zolmitriptan and sumatriptan as I have migraines for more than 15 - 20 days out of every month. I was given Duloxentine for severe back and nerve pain taken off my schedule lll drug that had zero side effects stopped my pain and my migraines because of the worlds reaction to addicts.