I m sorry that your wife has multiple sclerosis (MS) as well as severe headaches. First, headaches and MS very commonly occur together. Second, the headaches can still be classified. It sounds like you could be describing two types of headaches. One headache that is typically unilateral and severe is migraine and should be treated as such with triptans or non-steroidal anti-inflammatory drugs The other headache in the mouth could be what is called trigeminal neuralgia which often occurs in patients with MS. This is typically an electric or searing type pain that can last up to a couple of minutes and then subside but then return. Treatment for trigeminal neuralgia is usually antiseizure medicine such as carbamazepine. One recommended medicine that can help both types of headache would be gabapentin or even sodium divalproex. I highly recommend you see a neurologist or if possible, a headache specialist.