Hello dear, Understand your concern. Dear never pope up the lesion: it causes deep infection. Following are the cause of blistre near vagina 1. Bacterial infection: as it is moist area 2. STDs 3. Bartholin s cyst: Bartholin cyst generally not associated with pain if it is small and uninfected. But the burning pain inside the vagina may be due to genital tract infection. Bartholin cyst sometime get ruptured and lead to infection inside vagina. 4. Fungal infection 5. Dermatitis Following are the treatment: Use neosporin and hydrocortisone with cotrimazole for at least 72 hr. If Not response to ointment Maintain hygiene as below: Wear loose, cotton underwear Bathe or shower frequently Wash vagina with warm and salt water after urination to maintain hygiene Change out of sweaty or wet clothing as soon as possible Do use hygiene sprays add yogurt and other fermented foods to your diet to promote healthy bacteria Reduce the amount of sugar you eat. If not resolved consult gynecologist and do test for all above disease by following test. Pelvic examination Gram stain and culture PCR and nucleic acid amplification test:swab should be taken from urethra Hope this may help you. Best regards Dr. sagar