Hi, Thanks for posting in HCM. I understand your concern. Meprate contains Medroxyprogesterone . It is a form of progestin hormone, prescribed for menstrual problems, breast cancer and prevention of pregnancy. If you are not getting periods even after taking progesterone for 5 days, you need to take urine pregnancy test to see that you are actually not pregnant. Sometimes the cycles are delayed due to stress in family, profession, education, change of profession and change to new place. Also, in conditions like Polycystic ovarian disease (PCOD), it is common to have a long cycle with delay in periods. There could be also Thyroid hormone deficiency. Hence you need to get blood tested for thyroid profile , which will help in excluding hypothyroidism. If your pregnancy test is negative, then you must consult Gynecologist for proper evaluation and treatment of PCOD and hypothyroidism. Hope the information provided would be helpful. All the best.