Suggest Remedy For Hypertension

Sir, my mother has been suffering from SLE possibly since the end of 2002, but her disease was actually diagnosed at the end of 2004. Since then she has continuously been on Prednisolone, Hydroxychloroquine, Calcium tablets. The dosage of Prednisolone have four times been resumed from 40 mg daily and then tappered to 5 mg every alternate day. Once she was advised Cellcept (MMF) capsules and continued for One an half year. During her prolong illness she was under attack of Liver function disorder, Kidney function disorder, AION, Lacunar infarct two times. Her major problem is hypertension. Now, after 2nd Lacunar infarct her BP remains continuously high after being given several aggressive antihypertensives. At present, she is taking Hydroxychloroquine 400 mg daily, Wysolone 5 mg What should be her next course of medicine? Pls. advise, we are helpless. The Doctors are trying best without having their expected results.