Dear Peter, Alot has happened in the field of ulcerative colitis, and there are many different drugs available to help control the condition, let s start with the basic medicines available: 1.sulfasalazine and related derivates: these drugs are used to treat patients with mild to moderate disease, they are available in oral forms and as suppositories and enemas 2. steroids: help in controlling an acute flare, and once settled, the patient is usually taken off them 3. thiopurine derivates: if a patient doesn t respond to steroids or needs more than two steroid based regimens , these drugs are used. They help control the disease and mantain the state of remission. 4. methotrexate: used in cases not controlled by the thiopurine derivates 5. adalimumab, certolizumab, vedoluzimab: these drugs are used to control severe disease that doesn t respond to any of the above mentioned drugs. And if all fails, the option left behind is surgical treatment. This entails removal of the large intestine as a whole, with an initial opening on the stomach wall. Later on, this may be rejoined with a special pouch thereby allowing he passage of stool through the anus. I hope this description helps you. Do talk to your GI about all the options. Sometimes the colitis is slow to respond, maybe take a few weeks, so don t push your GI specialist to starting something new without waiting for an ample time, allowing the drugs effects to kick in. All the best!!