Hi Thanks for posting on HCM Chronic constipation is a long term side effect of opiate.However, there exist many other possible causes of this condition.Some may include: -Blockage in colon or rectum -Problem with nerves around the colon and rectum -Difficulty with muscles involved in elimination -Hormonal imbalances However, in your case, it could be due to opiate. I will suggest you try the following and if problem persist, you see your Doctor to investigate you for other possible causes listed above: *Take enough fluids *Eat enough fruits like soft pawpaw and avoid fruits like bananas *High fiber diet *You make take a laxative like duphalac If the problem persist, you may see your Doctor for reevaluation and a possible change of drug.I will also suggest you see your Doctor to investigate you for a functional colopathy. Hope this will help you Best regards