My wife is suffering from advanced stage of RA.,CRP is -ve,Anti CCp (ACCP) 5.11,She was on Mexate 10 once a week, Calcium supllements & wysone 5 (Steroid) since last 3 years, now doctor has stopped Wysone 5 and prescribed SAZo 500 ,She is having lot of pain and demormation in the hands 80%,Pl guide how she will be cured and avoid pain taking nuxoxia p Pain killer ,pl help