Hello thanks for asking from HCM I can understand your problem. You have tried medicines, lifestyle changes and exercise still the symptoms are persisting and you have symptoms like hopelessness, despair. Most of people suffering from depression respond to medicines but if they fail to respond then in resistant depression augmentation of conventional anti-depressants with mood stabilisers like Lithium, Lamotrigine is done. In some cases addition of thyroid hormone results in improvement. If you have already underwent trials of resistant depression treatment then other methods like brain stimulation methods can help. ECT or electroconvulsive have great role in resistant depression. There are no implants but some methods of stimulation help to decrease depression. Deep brain stimulation or Vagus nerve stimulation methods also have good role in depression. RTMS or repetitive trans cranial magnetic stimulation is very effective non-invasive modality for recurrent depression. Consult a good psychiatrist for treatment and evaluation. Thanks