Hi, Antidepressants: Tricyclic antidepressants like amitriptyline, nortriptyline, or imipramine, and newer antidepressants like duloxetine and venlafaxine, have been shown to help with neuropathic pain. These medications can take several weeks to start working, and side effects can include drowsiness, dry mouth, and constipation. * Anticonvulsants: Medications used to treat seizures, like gabapentin and pregabalin, are also commonly used to treat neuropathic pain. These medications work by calming overactive nerve impulses, which can alleviate pain. Side effects can include dizziness, drowsiness, and weight gain. * Topical creams: Lidocaine and capsaicin creams can be applied directly to the skin to provide relief from neuropathic pain. Lidocaine works by numbing the area, while capsaicin works by blocking pain signals. These creams can cause skin irritation or a burning sensation. * Physical therapy: Certain exercises and stretching techniques can help alleviate neuropathic pain. Physical therapy can also help improve mobility and reduce the risk of injury. * Nerve blocks: Local anesthetics or steroids can be injected near the affected nerves to provide temporary relief from neuropathic pain. This treatment may need to be repeated periodically. It s important to discuss these options with your doctor to determine which treatment would be best for your specific situation. They can help you weigh the risks and benefits of each option, and develop a personalized treatment plan. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Priyanka, General & Family Physician