So what is the biggest problem doctors are having with the medication Zyhydro? I have tried every pain med out there for chronic pain, having best results with dilaudid, but current doc wants something less potent. Have not tried Zohydro but would like to try. Went off dilaudid over two years ago, and having to work my way back through all the standards, tramadol,nucynta,reg. Vicodin,ocycontin, none being as effective as dilaudid ir. I have beenchronic pain patient for 10 years.