yes I have had a very serious sinus infection . 2 yrs ago when it first started . a buddy brought me a xtra zpack he had I took it and second day it was gone. I asked a wound dr I had at the time for a zpack script cause it came back real bad. come to find out she gave me script for methylprednisolone. after taking a cpl of these in a 6 mth period. I still have the infection. looked this stuff up and found out what it is and it isn't same thing I had first time. I have high blood pressure prostate cancer, sleep apneia,severe arthuritus,bone degeneration etc etc