Effective management of a case of Cornelia de Lange Syndrome requires consultation by geneticists, ophthalmologists, ENT specialists, neurologists, nephrologists, cardiologists, gastro-enterologists and nutritionists. The treatment protocol comprises of: • Managing the difficulties encountered whilst feeding; tackling of the hearing and visual impairments, congenital cardiac diseases, and urinary anomalies. • Early intervention is a must to handle psycho-motor delay effectively. • Visual memory can be enhanced through computer programs. • Tactile stimulation is advised so that the child can understand, retain information and carry out tasks optimally. • Gross and fine motor activities are to be stressed on, principally when it comes to activities that are performed everyday. • Surgical intervention is recommended in certain cases, particularly, to treat a cleft palate, pyloric stenosis, volvulus, dislocation of the hip, and undecsended testes.