Over the past 6 months to a year I have had major muscle loss in my legs. just the top portion of my lower leg. I have to drink water before bed and wear heavy socks all year long or I wake up with extreme cramps in legs and feet. Now I have a quarter of an inch perfectly round deep indention that is about a quarter inch deep in my leg under my right knee? No pain in or around it. What could this be a sign of?