Hello Welcome to HCM You have been on treatment of severe depression since last 8 years and currently having problem of loss of erection and other sexual problems. There could be many reason of erectile dysfunction in your case- - First reason is depression itself. Severe depression leads to loss of sexual pleasure, erectile dysfunction and decreased libido. - Second cause is chronic treatment of antidepressants. Antidepressants like SSRIs result in anorgasmia and delayed ejaculation in high doses when used for long times. These side effects result in loss of confidence. - Third possible reason is obesity. Obesity itself potentiate erection problems. Now coming to treatment- As I have mentioned earlier also that SSRI group of antidepressants increases sexual side effects. Some antidepressants like Mirtazepine, Trazodon, Bupropion etc help in maintaining sexual function normal. Trazodon even improves erection. I would advise you to consult your psychiatrist regarding erectile dysfunction and to add medicines which don t cause sexual side effects or improves them. Sildenafil is good drug to improve erectile dysfunction. Tadalafil is also related to this drug and help to improve erection. The drug should not be used in cases of high BP who are on nitrate drugs. Herbal medicines like Tantax Forte, Confido can also be used. These medicines are available even without need of prescription as they are herbal medicines. They help in improving erection in a lot of individuals. Hope this helps you, thanks