Hi and welcome to Healthcaremagic. Thank you for your query. I am Dr. Rommstein, I understand your concerns and I will try to help you as much as I can. There are some medications which may cause fatty liver, however, isotrettinion is not one of it, There are two main types of fatty liver disease so treatment depends on this: Alcoholic liver disease and Nonalcoholic fatty liver disease. You can get alcoholic liver disease from drinking lots of alcohol. It can even show up after a short period of heavy drinking, other causes are obesity and hepatitis B and C. If you have alcoholic liver disease and you are a heavy drinker, quitting is the most important thing you can do. Talk to your doctor about how to get help. If you don t stop you could get complications like alcoholic hepatitis or cirrhosis. Even if you have nonalcoholic fatty liver disease, it can help to avoid drinking. If you are overweight or obese, do what you can to gradually lose weight -- no more than 1 or 2 pounds a week. Eat a balanced and healthy diet and get regular exercise. Limit high-carb foods such as bread, grits, rice, potatoes, and corn. And cut down on drinks with lots of sugar like sports drinks and juice. This should lead to improvement. You should repeat your liver markers in 3-4 weeks. I hope I have answered you query. If you have any further questions you can contact us in every time. Kindly regards. Wish you a good health.