I ve been having calf pain on and off for two weeks. First calf lain for 6 days after a short haul flight. Went and had a d dimer and all negative. Took pain meda for a further 3 days then saw a specialist who did examination and ordered a second d dimer test. All negative.suggestsd ibuprofen for 3 days and thereafter all Pain went. Was off painkillers for 6 days and all good. Just did a long haul Flight 6 hours and next day same calf pain returned. Cold this be a clot they never picked up or could it be something related to muscle the toon/nerve issue. I think doctorate think I m exaggerating but concerned it is a clot.